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Article complet (PDF, 388 ko)Abstract The purpose of this study was to develop a taste-masked quinine sulphate dosage form as a .exible pediatric formulation tool. Pellets were produced as they o.er more .exibility to body weight dose adaptation and therefore represent an alternative to tablet breaking in pediatrics. Quinine sulphate pellets were produced via extrusion-spheronisation. Next pellets were coated using EudragitrR) E PO to obtain a taste-masked formulation. Using 15% dibutyl sebacate (based on polymer weight) as a plasticizer in the formulation caused rapid pellet agglomeration during storage at 40 °C and 75% relative humidity. Using stearic acid (15% based on polymer weight) as plasticizer yielded pellets which were less sensitive to sticking. Quinine sulphate release in water within the first 5 min of dissolution testing: 9.2%, 5.9% and 2.1% of the drug dose was released from pellets coated with 10%, 20% and 30% (w/w) Eudragit(R) E PO, respectively. These observations correlated well with the bitterness score of the formulations determined via the Astree electronic tongue and its Bitterness Prediction Module, showing that 20% (w/w) Eudragit(R) E PO was required to obtain a homogeneous fillm and to delay quinine sulphate release sufficiently to mask the bitterness after drug administration. In acid medium immediate quinine sulphate release was obtained. (c) 2006 Published by Elsevier B.V. Keywords: Pediatric formulation; Quinine sulphate; Pellets; Extrusion-spheronisation; Electronic tongue; Taste-masking; Eudragit(R) E PO
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Dernière publication : European Journal of Pharmaceutics and Biopharmaceutics, 2006
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Article complet (PDF, 388 ko)Abstract The purpose of this study was to develop a taste-masked quinine sulphate dosage form as a .exible pediatric formulation tool. Pellets were produced as they o.er more .exibility to body weight dose adaptation and therefore represent an alternative to tablet breaking in pediatrics. Quinine sulphate pellets were produced via extrusion-spheronisation. Next pellets were coated using EudragitrR) E PO to obtain a taste-masked formulation. Using 15% dibutyl sebacate (based on polymer weight) as a plasticizer in the formulation caused rapid pellet agglomeration during storage at 40 °C and 75% relative humidity. Using stearic acid (15% based on polymer weight) as plasticizer yielded pellets which were less sensitive to sticking. Quinine sulphate release in water within the first 5 min of dissolution testing: 9.2%, 5.9% and 2.1% of the drug dose was released from pellets coated with 10%, 20% and 30% (w/w) Eudragit(R) E PO, respectively. These observations correlated well with the bitterness score of the formulations determined via the Astree electronic tongue and its Bitterness Prediction Module, showing that 20% (w/w) Eudragit(R) E PO was required to obtain a homogeneous fillm and to delay quinine sulphate release sufficiently to mask the bitterness after drug administration. In acid medium immediate quinine sulphate release was obtained. (c) 2006 Published by Elsevier B.V. Keywords: Pediatric formulation; Quinine sulphate; Pellets; Extrusion-spheronisation; Electronic tongue; Taste-masking; Eudragit(R) E PO
Cliquez sur les mots soulignés pour voir les définitions ou être redirigé vers le site web correspondant.
Dernière publication : European Journal of Pharmaceutics and Biopharmaceutics, 2006
Accueil Curriculum Vitae Documentation Résultats du concours IR INRA 2008 Enseignement Publications Recherche Vulgarisation scientifique Thèse Agrégation de Sciences Physiques CAPES_CAPLP 2008 Liens Logiciels Développements Easypeak (TM) GlycerolSoft (TM) ProfileReader VueMicro (TM) Protection des oeuvres numériques Contact FORUM . . Muscisième visiteur
Vous êtes le
(c) Copyright Christophe Cordella :Tous droits réservés